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ORIGINAL ARTICLE
Year : 2015  |  Volume : 12  |  Issue : 4  |  Page : 247-250

A corrosive oesophageal burn model in rats: Double-lumen central venous catheter usage


1 Department of Pediatric Surgery, Faculty of Medicine, Turgut Ozal University, Ankara 06510, Turkey
2 Department of Pathology, Faculty of Medicine, Sütçü İmam University, Kahramanmaraş 46100, Turkey
3 Department of Anesthesiology and Reanimation, Faculty of Medicine, Turgut Ozal University, Ankara 06510, Turkey

Correspondence Address:
Dr. Vedat Bakan
Department of Pediatric Surgery, Faculty of Medicine, Turgut Ozal University, Ankara 06510
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0189-6725.172560

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Background: We aimed to create a new and less invasive experimental corrosive oesophageal burn model using a catheter without a gastric puncture (gastrotomy). Materials and Methods: We conducted the study with two groups composed of 8 male rats. The experimental oesophageal burn was established by the application of 10% sodium hydroxide to the distal oesophagus under a pressure of 20 cmH 2 O, via 5-F double-lumen central venous catheter without a gastrotomy. The control group was given 0.9% sodium chloride. All rats were killed 24 h after administration of NaOH or 0.9% NaCl. Histologic damage to oesophageal tissue was scored by a single pathologist blind to groups. Results: The rats in the control group were observed to have no pathological changes. Corrosive oesophagitis (tissue congestion, oedema, inflammation, ulcer and necrosis) was observed in rats exposed to NaOH. Conclusion: We believe that an experimental corrosive oesophageal burn can safely be created under same hydrostatic pressure without a gastric puncture using this model.


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