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LETTER TO THE EDITOR Table of Contents   
Year : 2017  |  Volume : 14  |  Issue : 3  |  Page : 60
Anti-smooth muscle antibodies and liver enzymes in differentiation of extrahepatic biliary atresia and idiopathic neonatal hepatitis: Concern in laboratory medicine view


1 Medical Academic Center, Bangkok, Thailand
2 Department of Medical Science, Faculty of Medicine, University of Nis, Nis, Serbia

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Date of Web Publication19-Mar-2018
 

How to cite this article:
Joob B, Wiwanitkit V. Anti-smooth muscle antibodies and liver enzymes in differentiation of extrahepatic biliary atresia and idiopathic neonatal hepatitis: Concern in laboratory medicine view. Afr J Paediatr Surg 2017;14:60

How to cite this URL:
Joob B, Wiwanitkit V. Anti-smooth muscle antibodies and liver enzymes in differentiation of extrahepatic biliary atresia and idiopathic neonatal hepatitis: Concern in laboratory medicine view. Afr J Paediatr Surg [serial online] 2017 [cited 2018 Dec 14];14:60. Available from: http://www.afrjpaedsurg.org/text.asp?2017/14/3/60/227849
Sir,

The recent report on 'anti-smooth muscle antibodies and liver enzymes in differentiation of extrahepatic biliary atresia and idiopathic neonatal hepatitis (INH)' is very interesting.[1] Rafeey et al. concluded that 'anti-smooth muscle antibodies (ASMA) may be a useful biomarker for differentiation of extrahepatic biliary atresia from idiopathic neonatal hepatitis (INH)'[1] and 'further studies with larger samples are recommended for confirming the results of this study'.[1] As noted by Rafeey et al.,[1] the main concern of this report is on the few cases. Nevertheless, there are also other concerns in laboratory medicine. First, the quality control of the investigation is very important.[2] Furthermore, the confirmation of INH has to be further rule out the possible problem from many viral hepatitis. For example, hepatitis, which can be transmitted from mother to offspring, can be the cause of aberrant ASMA results.[3]

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There are no conflicts of interest.

 
   References Top

1.
Rafeey M, Saboktakin L, Hasani JS, Naghashi S. Diagnostic value of anti-smooth muscle antibodies and liver enzymes in differentiation of extrahepatic biliary atresia and idiopathic neonatal hepatitis. Afr J Paediatr Surg 2016;13:63-8.  Back to cited text no. 1
[PUBMED]  [Full text]  
2.
Nakamura RM, Chisari FV, Edgington TS. Laboratory tests for diagnosis of autoimmune diseases. Prog Clin Pathol 1975;6:177-203.  Back to cited text no. 2
[PUBMED]    
3.
Hamed ME, Kamal Alanani NM, Sherief LM, Fouad MA, Elwahab LA, Raafat N. Study of non-organ-specific antibodies in children with genotype 4 chronic hepatitis C. Saudi J Gastroenterol 2013;19:262-70.  Back to cited text no. 3
[PUBMED]  [Full text]  

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Correspondence Address:
Dr. Beuy Joob
Medical Academic Center, Bangkok
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ajps.AJPS_65_16

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