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ORIGINAL ARTICLE
Year : 2015  |  Volume : 12  |  Issue : 2  |  Page : 105-113

A meta-analysis and systematic review of the prevalence of mitochondrially encoded 12S RNA in the general population: Is there a role for screening neonates requiring aminoglycosides?


1 Department of ENT, University of Abuja Teaching Hospital and College of Health Sciences, University of Abuja, Abuja, Nigeria
2 St. Paul's Rotary Hearing Clinic, Division of Otolaryngology-Head and Neck Surgery; Department of ENT, Division of Pediatric Otolaryngology, BC Children's Hospital, University of British Columbia, Vancouver, Canada
3 Department of ENT, Division of Pediatric Otolaryngology, BC Children's Hospital, University of British Columbia, Vancouver, Canada

Correspondence Address:
Titus S Ibekwe
Department of ENT, University of Abuja Teaching Hospital and College of Health Sciences, University of Abuja, P.M.B 117, Abuja
Nigeria
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Source of Support: The Global Surgery Foundation of the University of British Columbia supported with training grant during this study and a travel grant to the AAO-HNSF annual meeting where the paper was fi rst presented in 2012., Conflict of Interest: None


DOI: 10.4103/0189-6725.160342

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Background: This was a meta-analysis and systematic review to determine the global prevalence of the mitochondrially encoded 12S RNA (MT-RNR1) genetic mutation in order to assess the need for neonatal screening prior to aminoglycoside therapy. Materials and Methods: A comprehensive search of MEDLINE, EMBASE, Ovid, Database of Abstracts of Reviews of Effect, Cochrane Library, Clinical Evidence and Cochrane Central Register of Trials was performed including cross-referencing independently by 2 assessors. Selections were restricted to human studies in English. Meta-analysis was done with MetaXL 2013. Results: Forty-five papers out of 295 met the criteria. Pooled prevalence in the general population for MT-RNR1 gene mutations (A1555G, C1494T, A7445G) was 2% (1-4%) at 99%. Conclusion: Routine screening for MT-RNR1 mutations in the general population prior to treatment with aminoglycosides appear desirable but poorly supported by the weak level of evidence available in the literature. Routine screening in high-risk (Chinese and Spanish) populations appear justified.


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