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ORIGINAL ARTICLE Table of Contents   
Year : 2020  |  Volume : 17  |  Issue : 3  |  Page : 54-58
Ultrasonographic review of pediatric breast masses among Nigerian children in a tertiary hospital


Department of Radiology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria

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Date of Submission13-Jun-2017
Date of Decision05-May-2020
Date of Acceptance10-May-2020
Date of Web Publication19-Dec-2020
 

   Abstract 

X
Background: Breast masses occur infrequently in children and adolescents. Most of these masses have proved that benign and conservative approach is the management of choice. Consequently, imaging has become crucial. The knowledge of the ultrasonographic features of childhood and adolescent breast masses is needed for age appropriate medical care. Aim: The aim of this study was to describe and document the ultrasonographic spectrum of breast masses in children and adolescents (0–19) years seen in the Ahmadu Bello University teaching hospital, Zaria. Materials and Methods: A 2-year retrospective review of breast sonograms of 25 consecutively presenting children and adolescents (3 males and 22 females) who had palpable breast masses. Ultrasound scans were performed with a Mindray Machine DC-8 using the linear transducer at 7.5–12 MHz transducer frequency. Histopathological confirmation of the solid masses was also obtained. The statistical analysis of the data collected was done using the SPSS software version 20 (SPSS Inc., Chicago, IL, USA). Results: The patients were between 40 days and 19 years old (mean 14.8 years and standard deviation 4.1). The ultrasonographic findings were those of infections, benign tumoral lesions and pubertal endocrine changes. Overall, fibroadenoma was the most common mass, seen in 14 (56%) of the patients. Other findings were simple cysts, non-puerperal and puerperal mastitis, juvenile papillomatosis and normal glandular pubertal breast tissue. The three male patients had gynaecomstia, pseudogynaecomastia and cystic lymphangioma of the chest wall presenting as unilateral breast masses, respectively. There was no malignancy recorded in any of the patients. Conclusion: Ultrasonographically, benign masses predominate which is concordant with surgical findings. Familiarity with these features would obviate the need for unnecessary invasive procedures which should be reserved for only deserving cases.

Keywords: Breast, children, masses, palpable, ultrasonographic

How to cite this article:
Olarinoye-Akorede SA, Ibinaiye PO, Suleiman LB. Ultrasonographic review of pediatric breast masses among Nigerian children in a tertiary hospital. Afr J Paediatr Surg 2020;17:54-8

How to cite this URL:
Olarinoye-Akorede SA, Ibinaiye PO, Suleiman LB. Ultrasonographic review of pediatric breast masses among Nigerian children in a tertiary hospital. Afr J Paediatr Surg [serial online] 2020 [cited 2021 Jan 19];17:54-8. Available from: https://www.afrjpaedsurg.org/text.asp?2020/17/3/54/303992



   Introduction Top


The heightened level of awareness of breast cancer among adult population has increased the conspicuity of childhood breast conditions. Although breast masses are still less frequently encountered in children and adolescents,[1],[2],[3],[4] it could be associated with significant patient and parental distress. The prevalence of adolescent masses in a previous report is 3.25%.[3] Luckily, in the pediatric population, breast cancer is rare, occurring in 0.1% of cases.[5],[6],[7],[8] The few Nigerian literature on childhood and adolescent breast masses is clinicopathological.[2],[4],[5],[6],[7] We believe that the paucity of ultrasonographic data could be because breast ultrasound services were not available in some hospitals until recently[6] or simply due to a low threshold for biopsy by some surgeons.

Ultrasound is non-invasive which makes it central to the diagnosis, treatment, follow-up and intervention in paediatric patients. The advantage of this technique is minimal disruption of the sensitive growing breast buds which could impair breast development and breastfeeding later in life.

This presentation illustrated the ultrasonographic differential diagnoses of breast masses seen in children and adolescents in our centre.


   Materials and Methods Top


This study was a retrospective review of patients who underwent breast ultrasound scan during the 2-year study period. Two hundred and thirty-eight out of a total of 433 patients had palpable breast masses, of which only 25 patients (0.11%) were younger than 20 years of age. There were 3 males and 22 females that constituted our study population. The clinical notes and ultrasound images were reviewed for each patient. The ultrasound scan was performed in two orthogonal planes using a single Mindray DC-8 ultrasound machine (2008), at a probe frequency of 7.5–12 MHz. The findings recorded were side and number of the lesion, shape, margin, and echogenicity, presence of calcification, posterior acoustic features and vascularity. Histopathological confirmation of solid masses was also obtained. Data were recorded and analyzed using the SPSS software version 20 (SPSS Inc., Chicago, IL, USA).


   Results Top


Patient demographics

A total of 22 female and 3 male patients who were < 20 years old were studied, as shown in [Table 1]. The youngest patient was a 40-day-old infant, whereas the oldest patient was 19 years old. Three of the females were yet to attain menarche; only 1 patient had achieved parity. There was no history of oral contraceptive use among the female patients. Family history of breast cancer was present in only two patients.
Table 1: The patients' demographics

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Patient presentation

Twenty-nine breast masses were recorded in the 25 patients. Seven patients (28%) had multiple masses, whereas bilateral masses were seen in 4 (16%) patients. The mean duration of symptoms before the presentation was 6.2 months. Right sided masses predominated (60%).

Ultrasonographic findings

The most common abnormality was fibroadenoma, seen in 14 (56%) of the patients [Figure 1] and [Table 2]. Normal developmental (pubertal) breast tissue presenting as palpable masses was seen in a 7-year-old female child [Figure 2] and an 11-year-old male child. Other findings included breast cysts, one of which was complicated [Figure 3]; breast abscess [Figure 4]; juvenile papillomatosis [Figure 5]. In patient with a negative scan, the palpable concerned was the patient's rib.
Figure 1: A 17-year-old female with a right breast mass of 5 weeks duration. Ultrasound shows a well-defined oval-shaped hypoechoic mass At 6 o'clock position, 3 cm from the nipple. There is posterior acoustic enhancement with edge shadowing. Biopsy revealed fibroadenoma

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Figure 2: A 7-year-old female with asymmetric right breast mass. Ultrasound shows an echogenic breast tissue with central hypoechogenicity. Diagnosis: normal pubertal breasts (Tanner stage 3)

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Figure 3: A 15-year-old female with painless right breast mass of 6 months duration. Ultrasound shows a well-circumscribed anechoic masss with a thin wall and no internal septations. There is through transmission. Diagnosis simple breast cyst

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Figure 4: A 13-year-old female with a week history of painful right breast swelling and fever. Ultrasound shows an irregular anechoic area with internal debris. Ultrasound-guided per cutaneous drainage yielded pus. Diagnosis breast abscess

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Figure 5: A 13-year-old female with sudden rapidly enlarging right breast mass of 5 months duration. Ultrasound shows a heterogeneous mass with numerous cystic spaces within it. Biopsy revealed juvenile papillomatosis

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Table 2: Ultrasound findings in pediatric patients with complaints of breast mass

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Gynaecomastia, pseudogynaecomastia [Figure 6] and congenital chest wall cystic lymphangioma [Figure 7] constituted the male abnormalities.
Figure 6: A 15-year-old obese male child with bilateral breast enlargements. Ultrasound revealed excessive deposition of fatty tissue in both breasts, without proliferation of glandular breast tissue. Diagnosis: Pseudogynaecomastia

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Figure 7: A 40-day-old child with asymmetric swelling of the right chest wall and axilla. Ultrasound shows multiple anechoic cystic spaces just beneath the skin. Histology showed congenital cystic lymphangioma of the chest wall

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No histological confirmed malignancy was recorded in this study.


   Discussion Top


The paediatric and childhood masses documented in this study were all benign, and they include congenital, developmental, infective and benign neoplastic conditions. The mean age of the presentation is 14.8 ± 4.1 years. This is slightly lower than a study in Southern Nigeria,[6] but similar to the study in America.[9],[10]

Developmental lesions

Normal development of the breast (thelarche) occurs across an age spectrum, appearing earlier in African girls (7 years) than caucassian girls (8 years).[11] Sometimes, thelarche can occur earlier than expected, and it may be worrisome to parents, especially when it is asymmetric as it was in both cases presented. In the absence of precocious puberty, it is considered a variation of normal development. The use of ultrasound is to confirm normal developing breast tissue and to rule out other masses to avoid unnecessary procedure which could damage the breast bud or even cause iatrogenic amastia.[12] The pelvis should also be assessed to rule out early sexual development.

Gynaecomastia

Two out of the three male patients had gynaecomastia and pseudogynaecomastia. Gynaecomastia is the excessive proliferation of the glandular tissue in the male breast. It is usually bilateral, but it was unilateral and painful in the patient presented. In the pediatric age group, physiologic gynaecomastia occurs in the neonatal period and during puberty. Pubertal gynaecomastia occurs in about 60% of boys, with a peak age between 10 and 13 years.[13] Pseudogynaecomastia was seen in a 15 years old who was being managed at the endocrine clinic for obesity. In this case, the bilateral breast enlargement was due to increased deposition of subareolar adipose tissue without glandular proliferation. This differentiates it from gynaecomastia. Ultrasound findings demonstrate normal glandular breast tissue or fatty tissue as the case may be and excludes any other mass.

Infections (mastitis/abscess)

Paediatric mastitis has a bimodal occurrence; in infants under 2 months old and in children 8–17 years. The older group could be puerperal or non-puerperal. Patients present with painful breast swelling erythema and fever. The diagnosis is usually clinical; however, ultrasound is useful to confirm mastitis or abscess formation and to guide per cutaneous drainage procedure. Ultrasonographically, mastitis appears as an irregular hypoechoic or hyperechoic area with surrounding hyperaemia. This area becomes anechoic when abscess has formed or it appears as a complex cyst with reduced flow centrally. There may also be enlarged reactive lymphadenopathy.

Fibroadenomas

Fibroadenoma is the most common adolescent breast tumor,[10],[11] occurring more frequently in blacks.[12] Among Nigerians females, it is also the most common adolescent breast mass.[2],[4],[5],[7] In our study, it constituted more than half (56%) of all the childhood palpable abnormalities. In a 10-year study in Benin, fibroadenomas accounted for 54.8%, while in a 7-year study in Delta state, it was 75.4% of all adolescent masses.

Ultrasonographically, they may exhibit varying features. However, they are predominantly hypoechoic oval-shaped masses which are well defined. From our study, the ultrasonographic distribution of the Birads descriptors which include shape, echogenicity, margin, acoustic features, and vascularity were documented. Hypoechogenicity was demonstrated in 12 (86%) of the cases. Iso-echogenicity and heterogeneous echogenicity were seen only in one 1 case each. Nine (9) of the masses were oval in shape, whereas three were lobulated. Calcified fibroadenoma was seen in three patients. All cases were well defined and had no increased vascularity on Doppler interrogation.

About 10% of paediatric fibroadenomas are expected to regress spontaneously; therefore, short-term ultrasound follow-up is recommended.[13]

Juvenille papillomatosis

Juvenile papillomatosis is a benign proliferative tumour, which is rarely seen in children. It is similar in clinical presentation as fibroadenoma. The patient presented was a 14-year-old female who had a rapidly enlarging breast mass which was initially thought to be a juvenile fibroadenoma. Pathologically, the tumour is composed of numerous cysts and dilated ducts within a dense stroma hence appearing like a Swiss cheese.[14]

The sonographic features are those of a heterogeneous mass with multiple small anechoic areas which represents the cysts distributed peripherally. Juvenille fibromatosis constitutes a marker for both personal and family history of breast cancer.[10]

Simple cysts

Simple cysts are more common in adults; however, they still occur among adolescents. Historically, ultrasound was the main discriminatory imaging tool between cystic and solid masses. On ultrasound, a simple cyst appears anechoic, with well-defined wall, no internal echogenicity, and it shows posterior acoustic enhancement. When complicated by infection or haemorrhage, it may contain internal debris.

Rib

Sometimes, patients could mistake a rib for a palpable mass. However, US will reveal that a rib is located posterior to the linear striae of the retro mammary pectoralis muscle. It is hypoechoic and circular on cross-section while becoming tubular on longitudinal section. A rib is also associated with dense posterior shadowing.

Congenital chest wall abnormality

The youngest patient in our study was a 40-day-old male infant who had a congenital cystic lymphangioma involving the chest wall and axilla since birth. Ultrasound demonstrated multiseptated anechoic avascular lesions in the right hemithorax. He had ultrasound-guided sclerotherapy with bleomycin and surgery subsequently.

Malignancy

Primary breast malignancy is extremely rare in childhood, and it accounts for about 0.1% of all breast cancers.[15] Breast cancer tends to occur at a younger age group in adult Africans;[16] however, it is still a rarity among children. Only 1 case of primary breast cancer was documented by Umanah et al.[2] in Benin city, while Onuigbo[7] documented a metastatic ovarian cancer presenting as a breast mass in an Igbo community. No malignancy was encountered in our study.


   Conclusion Top


The spectrum of childhood and adolescent masses in our environment has been presented. Ultrasound with clinical correlation will help triage patients for appropriate management.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Simpson JS, Barson AJ. Breast tumors in infants and children. A 40 year review of cases at a children's hospital. Can Med Assoc J 1969;101:100-2.  Back to cited text no. 1
    
2.
Umanah IN, Akhiwu W, Ojo OS. Breast tumours of adolescents in an African population. Afr J Paediatr Surg 2010;7:78-80.  Back to cited text no. 2
[PUBMED]  [Full text]  
3.
Neinstein LS, Atkinson J, Diament M. Prevalence and longitudinal study of breast masses in adolescents. J Adolesc Health 1993;14:277-81.  Back to cited text no. 3
    
4.
Nwachokor F, Igbe AP, Forae GD. Histopathological review of breast tumours in children and adolescents in Delta State Nigeria. Afr J Paediatr Surg 2013;10:65-7.  Back to cited text no. 4
  [Full text]  
5.
Ozumba BC, Nzegwu MA, Anyikam A, Okoye I, Okafor OC. Breast disease in children and adolescents in eastern Nigeria–A five-year study. J Pediatr Adolesc Gynecol 2009;22:169-72.  Back to cited text no. 5
    
6.
Ademuyiwa AO, Lawal AO, Anunobi CC and Bode CO. Discrete breast masses in female children and adolescents: Is there a place for non-operative management by pediatric surgeons? BJMMR 2015;9:1-7.  Back to cited text no. 6
    
7.
Onuigbo WI. Adolescent breast masses in Nigerian Igbos. Am J Surg 1979;137:367-8.  Back to cited text no. 7
    
8.
Simmons PS. Diagnostic considerations in breast disorders of children and adolescents. Obstet Gynecol Clin North Am 1992;19:91-102.  Back to cited text no. 8
    
9.
Vade A, Lafita VS, Ward KA, Lim-Dunham JE, Bova D. Role of breast sonography in imaging of adolescents with palpable solid breast masses. AJR Am J Roentgenol 2008;191:659-63.  Back to cited text no. 9
    
10.
Kaneda HJ, Mack J, Kasales CJ, Schetter S. Pediatric and adolescent breast masses: A review of pathophysiology, imaging, diagnosis, and treatment. AJR Am J Roentgenol 2013;200:W204-12.  Back to cited text no. 10
    
11.
Chung EM, Cube R, Hall GJ, González C, Stocker JT, Glassman LM. From the archives of the AFIP: Breast masses in children and adolescents–radiologic-pathologic correlation. Radio-Graphics 2009;29:907-31.  Back to cited text no. 11
    
12.
Weinstein SP, Conant EF, Orel SG, Zuckerman JA, Bellah R. Spectrum of US findings in pediatric and adolescent patients with palpable breast masses. Radiographics 2000;20:1613-21.  Back to cited text no. 12
    
13.
West KW, Rescorla FJ, Scherer LR 3rd, Grosfeld JL. Diagnosis and treatment of symptomatic breast masses in the pediatric population. J Pediatr Surg 1995;30:182-6.  Back to cited text no. 13
    
14.
Rosen PP, Cantrell B, Mullen DL, DePalo A. Juvenile papillomatosis (Swiss cheese disease) of the breast. Am J Surg Pathol 1980;4:3-12.  Back to cited text no. 14
    
15.
Karl SR, Ballantine TV, Zaino R. Juvenile secretory carcinoma of the breast. J Pediatr Surg 1985;20:368-71.  Back to cited text no. 15
    
16.
Oluwole SF, Fadiran OA, Odesanmi WO. Diseases of the breast in Nigeria. Br J Surg 1987;74:582-5  Back to cited text no. 16
    

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Correspondence Address:
Dr. Sefiya Adebanke Olarinoye-Akorede
Department of Radiology, Ahmadu Bello University Teaching Hospital, Zaria
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ajps.AJPS_57_17

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